PGx Drug-Gene Associations

A Cross-Reference of PGx Drug-Gene Association Listings in FDA’s Table of Pharmacogenetic Associations and CPIC Clinical Guidelines

Conducted Quarterly by Manchester University

To help show how perspectives on personalized medicine are evolving at the U.S. Food and Drug Administration and the Clinical Pharmacogenetics Implementation Consortium, which is a leading developer of guidelines in personalized medicine, pharmacogenomics faculty members at Manchester University in Fort Wayne, Indiana, lead a team of Master of Science in Pharmacogenomics students through the following quarterly comparative analysis of FDA and CPIC’s resources regarding drug-gene associations that may have implications for prescribing and dosing decisions. By centralizing information about changes in drug-gene association information published by leading sources, this resource is designed to help researchers, genetic test developers, and health care decision-makers keep up with the latest thinking in the field. For questions or comments about the analysis, please contact Dave Kisor using the information provided below.

Results: January 2, 2024

According to the most recent cross-reference analysis, 217 drugs are listed with PGx information in FDA’s table, CPIC’s guidelines, or both. The results show that FDA’s table and CPIC’s guidelines overlap through the inclusion of 50 drugs listed by both sources. It is important to note, however, that FDA and CPIC often list differing gene associations and/or dosing implications in connection with those 50 drugs.

Below, you will find an online list of the drugs included in FDA’s table, CPIC’s guidelines, and both; a Venn diagram showing the numbers of drugs included in FDA’s table, CPIC’s guidelines, and both; a downloadable Excel document analyzing the information provided for each of the 50 drugs listed by both sources; and lists of changes made to the drug-gene associations listed in the two sources since March 1, 2022.

Download Information on 50 Drugs Named by Both CPIC and FDA

  • WHERE DRUGS NAMED BY FDA AND CPIC APPEAR: AS OF JANUARY 2, 2024

    Drugs Included in FDA's Table of Pharmacogenetic Associations and CPIC Clinical Guidelines: As of January 2, 2024  
  • DRUGS NAMED BY CPIC, FDA, OR BOTH: AS OF JANUARY 2, 2024

    CPIC Guidelines Only (103 Drugs) CPIC Guidelines and FDA Table (50 Drugs)* FDA Table Only (64 Drugs)
    1. Aceclofenac
    2. Alfentanil
    3. Amikacin
    4. Aminosalicylic acid
    5. Aspirin
    6. Atazanavir
    7. Buprenorphine
    8. Chloramphenicol
    9. Chloroquine
    10. Chlorpropamide
    11. Ciprofloxacin
    12. Dabrafenib
    13. Dapsone
    14. Desflurane
    15. Desvenlafaxine
    16. Dibekacin
    17. Diclofenac
    18. Dimercaprol
    19. Doxorubicin
    20. Duloxetine
    21. Enflurane
    22. Fentanyl
    23. Fluoxetine
    24. Fluvastatin
    25. Furazolidone
    26. Gentamicin
    27. Gliclazide
    28. Glimepiride
    29. Glipizide
    30. Glyburide
    31. Halothane
    32. Hydrocodone
    33. Hydromorphone
    34. Hydroxychloroquine
    35. Indomethacin
    36. Isoflurane
    37. Ivacaftor
    38. Kanamycin
    39. Levomethadone
    40. Levomilnacipran
    41. Lornoxicam
    42. Lovastatin
    43. Lumiracoxib
    44. Mafenide
    45. Mepacrine
    46. Mesalazine
    47. Metamizole
    48. Methadone
    49. Methoxyflurane
    50. Methylene blue
    51. Milnacipran
    52. Morphine
    53. Moxifloxacin
    54. Nabumetone
    55. Nalidixic acid
    56. Naltrexone
    57. Naproxen
    58. Neomycin
    59. Netilmicin
    60. Nicorandil
    61. Nitrofural
    62. Nitrofurantoin
    63. Norfloxacin
    64. Ofloxacin
    65. Ondansetron
    66. Oxycodone
    67. Paromomycin
    68. Peginterferon alfa-2a
    69. Peginterferon alfa-2b
    70. Pegloticase
    71. Phenazopyridine
    72. Pitavastatin
    73. Plazomicin
    74. Pravastatin
    75. Primaquine
    76. Probenecid
    77. Quinine
    78. Rasburicase
    79. Remifentanil
    80. Ribavirin
    81. Ribostamycin
    82. Sertraline
    83. Sevoflurane
    84. Sodium nitrite
    85. Streptomycin
    86. Sufentanil
    87. Sulfacetamide
    88. Sulfadiazine
    89. Sulfadimidine
    90. Sulfanilamide
    91. Sulfisoxazole
    92. Tafenoquine
    93. Tegafur
    94. Tenoxicam
    95. Tobramycin
    96. Tolazamide
    97. Tolbutamide
    98. Toluidine blue
    99. Trametinib
    100. Tropisetron
    101. Vilazodone
    102. Vitamin C
    103. Vitamin K
    1. Abacavir
    2. Allopurinol
    3. Amitriptyline
    4. Atomoxetine
    5. Atorvastatin
    6. Azathioprine
    7. Capecitabine
    8. Carbamazepine **
    9. Celecoxib
    10. Citalopram
    11. Clomipramine
    12. Clopidogrel
    13. Codeine **
    14. Desipramine
    15. Dexlansoprazole
    16. Doxepin
    17. Efavirenz
    18. Escitalopram
    19. Esomeprazole
    20. Fluorouracil
    21. Flurbiprofen
    22. Fluvoxamine
    23. Fosphenytoin
    24. Ibuprofen
    25. Imipramine
    26. Lansoprazole
    27. Meloxicam
    28. Mercaptopurine
    29. Nortriptyline
    30. Omeprazole
    31. Oxcarbazepine
    32. Pantoprazole
    33. Paroxetine
    34. Phenytoin
    35. Piroxicam
    36. Rabeprazole
    37. Rosuvastatin
    38. Simvastatin
    39. Succinylcholine
    40. Sulfamethoxazole/Trimethoprim
    41. Sulfasalazine
    42. Tacrolimus
    43. Tamoxifen
    44. Thioguanine
    45. Tramadol **
    46. Trimipramine
    47. Venlafaxine
    48. Voriconazole
    49. Vortioxetine
    50. Warfarin
    1. Abrocitinib
    2. Amifampridine
    3. Amifampridine phosphate
    4. Amoxapine
    5. Amphetamine
    6. Aripiprazole
    7. Aripiprazole lauroxil
    8. Avatrombopag
    9. Belinostat
    10. Belzutifan
    11. Brexpiprazole
    12. Brivaracetam
    13. Carisoprodol
    14. Carvedilol
    15. Cevimeline
    16. Clobazam
    17. Clozapine
    18. Darifenacin
    19. Deutetrabenazine
    20. Diazepam
    21. Dolutegravir
    22. Donepezil
    23. Dronabinol
    24. Elagolix
    25. Eliglustat
    26. Erdafitinib
    27. Fesoterodine
    28. Flibanserin
    29. Galantamine
    30. Gefitinib
    31. Hydralazine
    32. Iloperidone
    33. Irinotecan
    34. Isoniazid
    35. Lapatinib
    36. Lofexidine
    37. Mavacamten
    38. Meclizine
    39. Metoclopramide
    40. Metoprolol
    41. Mirabegron
    42. Mivacurium
    43. Nateglinide
    44. Nebivolol
    45. Nilotinib
    46. Oliceridine
    47. Pazopanib
    48. Perphenazine
    49. Pimozide
    50. Pitolisant
    51. Procainamide
    52. Propafenone
    53. Propranolol
    54. Protriptyline
    55. Raltegravir
    56. Risperidone
    57. Sacituzumab
    58. Siponimod
    59. Tamsulosin
    60. Tetrabenazine
    61. Thioridazine
    62. Tolterodine
    63. Valbenazine
    64. Viloxazine
     
    Abbreviations: CPIC (Clinical Pharmacogenetics Implementation Consortium); FDA (Food and Drug Administration); PK (pharmacokinetics). * Reflects CPIC provisional levels. ** Carbamazepine, codeine, and tramadol are listed in two FDA sections for different gene-drug associations.
  • CHANGE LOG: MARCH 28 - JUNE 30, 2023

     
    Drug From: To:
    Desvenlafaxine Not listed by either source. CPIC's guidelines only.
    Duloxetine Not listed by either source. CPIC's guidelines only.
    Fluoxetine Not listed by either source. CPIC's guidelines only.
    Levomilnacipran Not listed by either source. CPIC's guidelines only.
    Milnacipran Not listed by either source. CPIC's guidelines only.
    Vilazodone Not listed by either source. CPIC's guidelines only.
    Venlafaxine FDA's table only. CPIC's guidelines and FDA's table.
    Vortioxetine FDA's table only. CPIC's guidelines and FDA's table.
  • CHANGE LOG: JANUARY 4, 2023 - MARCH 28, 2023

    Drug From: To:
    Dibekacin Not listed by either source. CPIC's guidelines only.
    Neomycin Not listed by either source. CPIC's guidelines only.
    Netilmicin Not listed by either source. CPIC's guidelines only.
    Ribostamycin Not listed by either source. CPIC's guidelines only.
  • CHANGE LOG: SEPTEMBER 28, 2022 - JANUARY 4, 2023

    Drug From: To:
    Trimipramine CPIC's guidelines only. CPIC's guidelines and FDA's table.
    Abrocitinib Not listed by either source. FDA's table only.
    Nateglinide Not listed by either source. FDA's table only.
    Mavacamten Not listed by either source. FDA's table only.
  • CHANGE LOG: JULY 8, 2022 - SEPTEMBER 28, 2022

    Drug From: To:
    Tramadol CPIC's guidelines and FDA's table. Updated/additional entry in CPIC's guidelines and FDA's table under "Potential Impact on Safety/Response."
    Esomeprazole FDA's table only. CPIC's guidelines and FDA's table.
    Rabeprazole FDA's table only. CPIC's guidelines and FDA's table.
    Sulfamethoxazole/trimethoprim FDA's table only. CPIC's guidelines and FDA's table.
    Sulfasalazine FDA's table only. CPIC's guidelines and FDA's table.
    Aceclofenac Not listed by either source. CPIC's guidelines only.
    Alfentanil Not listed by either source. CPIC's guidelines only.
    Aminosalicylic acid Not listed by either source. CPIC's guidelines only.
    Aspirin Not listed by either source. CPIC's guidelines only.
    Buprenorphine Not listed by either source. CPIC's guidelines only.
    Chloramphenicol Not listed by either source. CPIC's guidelines only.
    Chloroquine Not listed by either source. CPIC's guidelines only.
    Chlorpropamide Not listed by either source. CPIC's guidelines only.
    Ciprofloxacin Not listed by either source. CPIC's guidelines only.
    Dabrafenib Not listed by either source. CPIC's guidelines only.
    Dapsone Not listed by either source. CPIC's guidelines only.
    Dicolfenac Not listed by either source. CPIC's guidelines only.
    Dimercaprol Not listed by either source. CPIC's guidelines only.
    Doxorubicin Not listed by either source. CPIC's guidelines only.
    Fentanyl Not listed by either source. CPIC's guidelines only.
    Furazolidone Not listed by either source. CPIC's guidelines only.
    Gliclazide Not listed by either source. CPIC's guidelines only.
    Glimepiride Not listed by either source. CPIC's guidelines only.
    Glipizide Not listed by either source. CPIC's guidelines only.
    Glyburide Not listed by either source. CPIC's guidelines only.
    Hydromorphone Not listed by either source. CPIC's guidelines only.
    Hydroxychloroquine Not listed by either source. CPIC's guidelines only.
    Indomethacin Not listed by either source. CPIC's guidelines only.
    Levomethadone Not listed by either source. CPIC's guidelines only.
    Lumiracoxib Not listed by either source. CPIC's guidelines only.
    Mafenide Not listed by either source. CPIC's guidelines only.
    Mepacrine Not listed by either source. CPIC's guidelines only.
    Mesalazine Not listed by either source. CPIC's guidelines only.
    Metamizole Not listed by either source. CPIC's guidelines only.
    Methadone Not listed by either source. CPIC's guidelines only.
    Methylene blue Not listed by either source. CPIC's guidelines only.
    Morphine Not listed by either source. CPIC's guidelines only.
    Moxifloxacin Not listed by either source. CPIC's guidelines only.
    Nabumetone Not listed by either source. CPIC's guidelines only.
    Nalidixic acid Not listed by either source. CPIC's guidelines only.
    Naltrexone Not listed by either source. CPIC's guidelines only.
    Naproxen Not listed by either source. CPIC's guidelines only.
    Nicorandil Not listed by either source. CPIC's guidelines only.
    Nitrofural Not listed by either source. CPIC's guidelines only.
    Nitrofurantoin Not listed by either source. CPIC's guidelines only.
    Norfloxacin Not listed by either source. CPIC's guidelines only.
    Ofloxacin Not listed by either source. CPIC's guidelines only.
    Oxycodone Not listed by either source. CPIC's guidelines only.
    Pegloticase Not listed by either source. CPIC's guidelines only.
    Phenazopyridine Not listed by either source. CPIC's guidelines only.
    Primaquine Not listed by either source. CPIC's guidelines only.
    Probenecid Not listed by either source. CPIC's guidelines only.
    Quinine Not listed by either source. CPIC's guidelines only.
    Rasburicase Not listed by either source. CPIC's guidelines only.
    Remifentanil Not listed by either source. CPIC's guidelines only.
    Ribavirin Not listed by either source. CPIC's guidelines only.
    Sodium nitrite Not listed by either source. CPIC's guidelines only.
    Sufentanil Not listed by either source. CPIC's guidelines only.
    Sulfacetamide Not listed by either source. CPIC's guidelines only.
    Sulfadiazine Not listed by either source. CPIC's guidelines only.
    Sulfadimidine Not listed by either source. CPIC's guidelines only.
    Sulfanilamide Not listed by either source. CPIC's guidelines only.
    Sulfisoxazole Not listed by either source. CPIC's guidelines only.
    Tafenoquine Not listed by either source. CPIC's guidelines only.
    Tegafur Not listed by either source. CPIC's guidelines only.
    Tolazamide Not listed by either source. CPIC's guidelines only.
    Tolbutamide Not listed by either source. CPIC's guidelines only.
    Toluidine blue Not listed by either source. CPIC's guidelines only.
    Trametinib Not listed by either source. CPIC's guidelines only.
    Vitamin C Not listed by either source. CPIC's guidelines only.
    Vitamin K Not listed by either source. CPIC's guidelines only.
  • CHANGE LOG: APRIL 6, 2022 - JULY 8, 2022

    Drug From: To:
    Amikacin Not listed by either source. CPIC's guidelines only.
    Gentamicin Not listed by either source. CPIC's guidelines only.
    Kanamycin Not listed by either source. CPIC's guidelines only.
    Paromomycin Not listed by either source. CPIC's guidelines only.
    Plazomicin Not listed by either source. CPIC's guidelines only.
    Streptomycin Not listed by either source. CPIC's guidelines only.
    Tobramycin Not listed by either source. CPIC's guidelines only.
    Fluvastatin Not listed by either source. CPIC's guidelines only.
    Lovastatin Not listed by either source. CPIC's guidelines only.
    Pitavastatin Not listed by either source. CPIC's guidelines only.
    Pravastatin Not listed by either source. CPIC's guidelines only.
    Belzutifan Not listed by either source. FDA's table only.
    Lansoprazole CPIC's guidelines only. CPIC's guidelines and FDA's table.
  • CHANGE LOG: MARCH 1, 2022 - APRIL 6, 2022

    Drug From: To:
    Fosphenytoin CPIC's guidelines only. CPIC's guidelines and FDA's table.
    Phenytoin CPIC's guidelines only. CPIC's guidelines and FDA's table.
    Atorvastatin FDA's table only. CPIC's guidelines and FDA's table.
    Rosuvastatin FDA's table only. CPIC's guidelines and FDA's table.
    Viloxazine Not listed by either source. FDA's table only.
    Biomarker From: To:
    NUDT15 PharmGKB 2B PharmGKB 1A
    Drug-Biomarker From: To:
    Succinylcholine-BCHE CPIC C/D CPIC B/C
    Tramadol-CYP2D6 PharmGKB 1B PharmGKB 1A