Research Tables

A Cross-Reference of PGx Drug-Gene Association Listings in FDA’s Table of Pharmacogenetic Associations and CPIC Clinical Guidelines

Conducted Quarterly by Manchester University

To help show how perspectives on personalized medicine are evolving at the U.S. Food and Drug Administration and the Clinical Pharmacogenetics Implementation Consortium, which is a leading developer of guidelines in personalized medicine, Pharmacogenomics faculty members at Manchester University in Fort Wayne, Indiana, lead a team of Master of Science in Pharmacogenomics students through the following quarterly comparative analysis of FDA and CPIC’s resources regarding drug-gene associations that may have implications for prescribing and dosing decisions. By centralizing information about changes in drug-gene association information published by leading sources, this resource is designed to help researchers, genetic test developers, and health care decision-makers keep up with the latest thinking in the field.

Results: January 4, 2023

According to the most recent cross-reference analysis, 207 drugs are listed with PGx information in FDA’s table, CPIC’s guidelines, or both. The results show that FDA’s table and CPIC’s guidelines overlap through the inclusion of 48 drugs listed by both sources. It is important to note, however, that FDA and CPIC often list differing gene associations and/or dosing implications in connection with those 48 drugs.

Below, you will find an online list of the drugs included in FDA’s table, CPIC’s guidelines, and both; a Venn diagram showing the numbers of drugs included in FDA’s table, CPIC’s guidelines, and both; a downloadable Excel document analyzing the information provided for each of the 48 drugs listed by both sources; and lists of changes made to the drug-gene associations listed in the two sources since the publication of PMC’s original comparative analysis on March 1, 2022.

Download Information on 48 Drugs Named by Both CPIC and FDA

  • DRUGS NAMED BY CPIC, FDA, OR BOTH: AS OF MARCH 28, 2023

    CPIC Guidelines Only (97 Drugs) CPIC Guidelines and FDA Table (48 Drugs)* FDA Table Only (66 Drugs)
    1. Aceclofenac
    2. Alfentanil
    3. Amikacin
    4. Aminosalicylic acid
    5. Aspirin
    6. Atazanavir
    7. Buprenorphine
    8. Chloramphenicol
    9. Chloroquine
    10. Chlorpropamide
    11. Ciprofloxacin
    12. Dabrafenib
    13. Dapsone
    14. Desflurane
    15. Dibekacin
    16. Diclofenac
    17. Dimercaprol
    18. Doxorubicin
    19. Enflurane
    20. Fentanyl
    21. Fluvastatin
    22. Furazolidone
    23. Gentamicin
    24. Gliclazide
    25. Glimepiride
    26. Glipizide
    27. Glyburide
    28. Halothane
    29. Hydrocodone
    30. Hydromorphone
    31. Hydroxychloroquine
    32. Indomethacin
    33. Isoflurane
    34. Ivacaftor
    35. Kanamycin
    36. Levomethadone
    37. Lornoxicam
    38. Lovastatin
    39. Lumiracoxib
    40. Mafenide
    41. Mepacrine
    42. Mesalazine
    43. Metamizole
    44. Methadone
    45. Methoxyflurane
    46. Methylene blue
    47. Morphine
    48. Moxifloxacin
    49. Nabumetone
    50. Nalidixic acid
    51. Naltrexone
    52. Naproxen
    53. Neomycin
    54. Netilmicin
    55. Nicorandil
    56. Nitrofural
    57. Nitrofurantoin
    58. Norfloxacin
    59. Ofloxacin
    60. Ondansetron
    61. Oxycodone
    62. Paromomycin
    63. Peginterferon alfa-2a
    64. Peginterferon alfa-2b
    65. Pegloticase
    66. Phenazopyridine
    67. Pitavastatin
    68. Plazomicin
    69. Pravastatin
    70. Primaquine
    71. Probenecid
    72. Quinine
    73. Rasburicase
    74. Remifentanil
    75. Ribavirin
    76. Ribostamycin
    77. Sertraline
    78. Sevoflurane
    79. Sodium nitrite
    80. Streptomycin
    81. Sufentanil
    82. Sulfacetamide
    83. Sulfadiazine
    84. Sulfadimidine
    85. Sulfanilamide
    86. Sulfisoxazole
    87. Tafenoquine
    88. Tegafur
    89. Tenoxicam
    90. Tobramycin
    91. Tolazamide
    92. Tolbutamide
    93. Toluidine blue
    94. Trametinib
    95. Tropisetron
    96. Vitamin C
    97. Vitamin K
    1. Abacavir
    2. Allopurinol
    3. Amitriptyline
    4. Atomoxetine
    5. Atorvastatin
    6. Azathioprine
    7. Capecitabine
    8. Carbamazepine **
    9. Celecoxib
    10. Citalopram
    11. Clomipramine
    12. Clopidogrel
    13. Codeine **
    14. Desipramine
    15. Dexlansoprazole
    16. Doxepin
    17. Efavirenz
    18. Escitalopram
    19. Esomeprazole
    20. Fluorouracil
    21. Flurbiprofen
    22. Fluvoxamine
    23. Fosphenytoin
    24. Ibuprofen
    25. Imipramine
    26. Lansoprazole
    27. Meloxicam
    28. Mercaptopurine
    29. Nortriptyline
    30. Omeprazole
    31. Oxcarbazepine
    32. Pantoprazole
    33. Paroxetine
    34. Phenytoin
    35. Piroxicam
    36. Rabeprazole
    37. Rosuvastatin
    38. Simvastatin
    39. Succinylcholine
    40. Sulfamethoxazole/Trimethoprim
    41. Sulfasalazine
    42. Tacrolimus
    43. Tamoxifen
    44. Thioguanine
    45. Tramadol **
    46. Trimipramine
    47. Voriconazole
    48. Warfarin
    1. Abrocitinib
    2. Amifampridine
    3. Amifampridine phosphate
    4. Amoxapine
    5. Amphetamine
    6. Aripiprazole
    7. Aripiprazole lauroxil
    8. Avatrombopag
    9. Belinostat
    10. Belzutifan
    11. Brexpiprazole
    12. Brivaracetam
    13. Carisoprodol
    14. Carvedilol
    15. Cevimeline
    16. Clobazam
    17. Clozapine
    18. Darifenacin
    19. Deutetrabenazine
    20. Diazepam
    21. Dolutegravir
    22. Donepezil
    23. Dronabinol
    24. Elagolix
    25. Eliglustat
    26. Erdafitinib
    27. Fesoterodine
    28. Flibanserin
    29. Galantamine
    30. Gefitinib
    31. Hydralazine
    32. Iloperidone
    33. Irinotecan
    34. Isoniazid
    35. Lapatinib
    36. Lofexidine
    37. Mavacamten
    38. Meclizine
    39. Metoclopramide
    40. Metoprolol
    41. Mirabegron
    42. Mivacurium
    43. Nateglinide
    44. Nebivolol
    45. Nilotinib
    46. Oliceridine
    47. Pazopanib
    48. Perphenazine
    49. Pimozide
    50. Pitolisant
    51. Procainamide
    52. Propafenone
    53. Propranolol
    54. Protriptyline
    55. Raltegravir
    56. Risperidone
    57. Sacituzumab
    58. Siponimod
    59. Tamsulosin
    60. Tetrabenazine
    61. Thioridazine
    62. Tolterodine
    63. Valbenazine
    64. Venlafaxine
    65. Viloxazine
    66. Vortioxetine
     
    Abbreviations: CPIC (Clinical Pharmacogenetics Implementation Consortium); FDA (Food and Drug Administration); PK (pharmacokinetics). * Reflects CPIC provisional levels. ** Carbamazepine, codeine, and tramadol are listed in two FDA sections for different gene-drug associations.
  • WHERE DRUGS NAMED BY FDA AND CPIC APPEAR: AS OF MARCH 28, 2023

    Drugs Included in FDA's Table of Pharmacogenetic Associations and CPIC Clinical Guidelines: AS OF MARCH 28, 2023  
  • INFORMATION ON 48 DRUGS NAMED BY BOTH CPIC AND FDA: AS OF MARCH 28, 2023

  • CHANGE LOG: JANUARY 4, 2023 - MARCH 28, 2023

    Drug From: To:
    Dibekacin Not listed by either source. CPIC's guidelines only.
    Neomycin Not listed by either source. CPIC's guidelines only.
    Netilmicin Not listed by either source. CPIC's guidelines only.
    Ribostamycin Not listed by either source. CPIC's guidelines only.
  • CHANGE LOG: SEPTEMBER 28, 2022 - JANUARY 4, 2023

    Drug From: To:
    Trimipramine CPIC's guidelines only. CPIC's guidelines and FDA's table.
    Abrocitinib Not listed by either source. FDA's table only.
    Nateglinide Not listed by either source. FDA's table only.
    Mavacamten Not listed by either source. FDA's table only.
  • CHANGE LOG: JULY 8, 2022 - SEPTEMBER 28, 2022

    Drug From: To:
    Tramadol CPIC's guidelines and FDA's table. Updated/additional entry in CPIC's guidelines and FDA's table under "Potential Impact on Safety/Response."
    Esomeprazole FDA's table only. CPIC's guidelines and FDA's table.
    Rabeprazole FDA's table only. CPIC's guidelines and FDA's table.
    Sulfamethoxazole/trimethoprim FDA's table only. CPIC's guidelines and FDA's table.
    Sulfasalazine FDA's table only. CPIC's guidelines and FDA's table.
    Aceclofenac Not listed by either source. CPIC's guidelines only.
    Alfentanil Not listed by either source. CPIC's guidelines only.
    Aminosalicylic acid Not listed by either source. CPIC's guidelines only.
    Aspirin Not listed by either source. CPIC's guidelines only.
    Buprenorphine Not listed by either source. CPIC's guidelines only.
    Chloramphenicol Not listed by either source. CPIC's guidelines only.
    Chloroquine Not listed by either source. CPIC's guidelines only.
    Chlorpropamide Not listed by either source. CPIC's guidelines only.
    Ciprofloxacin Not listed by either source. CPIC's guidelines only.
    Dabrafenib Not listed by either source. CPIC's guidelines only.
    Dapsone Not listed by either source. CPIC's guidelines only.
    Dicolfenac Not listed by either source. CPIC's guidelines only.
    Dimercaprol Not listed by either source. CPIC's guidelines only.
    Doxorubicin Not listed by either source. CPIC's guidelines only.
    Fentanyl Not listed by either source. CPIC's guidelines only.
    Furazolidone Not listed by either source. CPIC's guidelines only.
    Gliclazide Not listed by either source. CPIC's guidelines only.
    Glimepiride Not listed by either source. CPIC's guidelines only.
    Glipizide Not listed by either source. CPIC's guidelines only.
    Glyburide Not listed by either source. CPIC's guidelines only.
    Hydromorphone Not listed by either source. CPIC's guidelines only.
    Hydroxychloroquine Not listed by either source. CPIC's guidelines only.
    Indomethacin Not listed by either source. CPIC's guidelines only.
    Levomethadone Not listed by either source. CPIC's guidelines only.
    Lumiracoxib Not listed by either source. CPIC's guidelines only.
    Mafenide Not listed by either source. CPIC's guidelines only.
    Mepacrine Not listed by either source. CPIC's guidelines only.
    Mesalazine Not listed by either source. CPIC's guidelines only.
    Metamizole Not listed by either source. CPIC's guidelines only.
    Methadone Not listed by either source. CPIC's guidelines only.
    Methylene blue Not listed by either source. CPIC's guidelines only.
    Morphine Not listed by either source. CPIC's guidelines only.
    Moxifloxacin Not listed by either source. CPIC's guidelines only.
    Nabumetone Not listed by either source. CPIC's guidelines only.
    Nalidixic acid Not listed by either source. CPIC's guidelines only.
    Naltrexone Not listed by either source. CPIC's guidelines only.
    Naproxen Not listed by either source. CPIC's guidelines only.
    Nicorandil Not listed by either source. CPIC's guidelines only.
    Nitrofural Not listed by either source. CPIC's guidelines only.
    Nitrofurantoin Not listed by either source. CPIC's guidelines only.
    Norfloxacin Not listed by either source. CPIC's guidelines only.
    Ofloxacin Not listed by either source. CPIC's guidelines only.
    Oxycodone Not listed by either source. CPIC's guidelines only.
    Pegloticase Not listed by either source. CPIC's guidelines only.
    Phenazopyridine Not listed by either source. CPIC's guidelines only.
    Primaquine Not listed by either source. CPIC's guidelines only.
    Probenecid Not listed by either source. CPIC's guidelines only.
    Quinine Not listed by either source. CPIC's guidelines only.
    Rasburicase Not listed by either source. CPIC's guidelines only.
    Remifentanil Not listed by either source. CPIC's guidelines only.
    Ribavirin Not listed by either source. CPIC's guidelines only.
    Sodium nitrite Not listed by either source. CPIC's guidelines only.
    Sufentanil Not listed by either source. CPIC's guidelines only.
    Sulfacetamide Not listed by either source. CPIC's guidelines only.
    Sulfadiazine Not listed by either source. CPIC's guidelines only.
    Sulfadimidine Not listed by either source. CPIC's guidelines only.
    Sulfanilamide Not listed by either source. CPIC's guidelines only.
    Sulfisoxazole Not listed by either source. CPIC's guidelines only.
    Tafenoquine Not listed by either source. CPIC's guidelines only.
    Tegafur Not listed by either source. CPIC's guidelines only.
    Tolazamide Not listed by either source. CPIC's guidelines only.
    Tolbutamide Not listed by either source. CPIC's guidelines only.
    Toluidine blue Not listed by either source. CPIC's guidelines only.
    Trametinib Not listed by either source. CPIC's guidelines only.
    Vitamin C Not listed by either source. CPIC's guidelines only.
    Vitamin K Not listed by either source. CPIC's guidelines only.
  • CHANGE LOG: APRIL 6, 2022 - JULY 8, 2022

    DrugFrom:
    To:
    Amikacin
    Not listed by either source.CPIC's guidelines only.
    Gentamicin
    Not listed by either source.
    CPIC's guidelines only.
    Kanamycin
    Not listed by either source.CPIC's guidelines only.
    Paromomycin
    Not listed by either source.
    CPIC's guidelines only.
    Plazomicin
    Not listed by either source.CPIC's guidelines only.
    Streptomycin
    Not listed by either source.
    CPIC's guidelines only.
    Tobramycin
    Not listed by either source.CPIC's guidelines only.
    Fluvastatin
    Not listed by either source.
    CPIC's guidelines only.
    Lovastatin
    Not listed by either source.CPIC's guidelines only.
    Pitavastatin
    Not listed by either source.
    CPIC's guidelines only.
    Pravastatin
    Not listed by either source.CPIC's guidelines only.
    Belzutifan
    Not listed by either source.
    FDA's table only.
    Lansoprazole
    CPIC's guidelines only.CPIC's guidelines and FDA's table.
  • CHANGE LOG: MARCH 1, 2022 - APRIL 6, 2022

    DrugFrom:
    To:
    Fosphenytoin
    CPIC's guidelines only.CPIC's guidelines and FDA's table.
    Phenytoin
    CPIC's guidelines only.
    CPIC's guidelines and FDA's table.
    Atorvastatin
    FDA's table only.CPIC's guidelines and FDA's table.
    Rosuvastatin
    FDA's table only.
    CPIC's guidelines and FDA's table.
    Viloxazine
    Not listed by either source.FDA's table only.
    BiomarkerFrom:
    To:
    NUDT15
    PharmGKB 2B
    PharmGKB 1A
    Drug-BiomarkerFrom:
    To:
    Succinylcholine-BCHE
    CPIC C/DCPIC B/C
    Tramadol-CYP2D6
    PharmGKB 1B
    PharmGKB 1A