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Therapies

As of September 2016

Click on the "+" icons below to view tables with information on selected personalized therapies and their indications.

  • ADJUVANT THERAPY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Cevimeline
      (Evoxac ®)
      CYP2D6
      Dry mouth
      Rasburicase
      (Elitek ®)
      G6PD; CYB5R1-4
      Hyperuricemia, hemolysis, and methemoglobinemia
      Sodium phenylacetate & sodium benzoate (Ammonul ®)
      NAGS; CPS1; ASS1; OTC; ASL; ARG
      Urea cycle disorders
      Sodium phenylbutyrate
      (Buphenyl ®)
      CPS1; OTC; ASS1
      Urea cycle disorders
  • ANALGESIA & ANESTHESIOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Celecoxib
      (Celebrex ®)
      CYP2C9
      Pain
      Codeine
      CYP2D6; CYP3A4; UGT2B7
      Pain
      Mivacurium
      (Mivacron ®)
      Cholinesterase gene
      Anesthesia adjunct
      Tramadol
      (Ultram ®)
      CYP2D6
      Pain
  • CARDIOVASCULAR (CV)
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Carvedilol
      (Coreg ®)
      CYP2D6
      Cardiovascular disease
      Clopidogrel
      (Plavix ®)
      CYP2C19
      Antiplatelet response
      Isosorbide and hydralazine
      (Bidil ®)
      NAT1; NAT2
      Heart failure
      Lomitapide
      LDLR
      Familial hypercholesterolemia
      Metoprolol
      (Toprol-XL ®)
      CYP2D6
      Cardiovascular disease
      Mipomersen sodium
      (Kynamro ®)
      LDLR
      Familial hypercholesterolemia
      Pravastatin
      LDR
      High cholesterol
      Propafenone
      (Rythmol SR ®)
      CYP2D6
      Cardiac arrhythmia
      Quinidine
      CYP2D6
      Cardiac arrhythmia, malaria
      Simvastatin
      (Zocor ®)
      SLCO1B1
      High cholesterol
      Warfarin
      (Coumadin ®)
      CYP2C9; VKORC1; protein C or S deficiencies
      Anti-blood clotting, stroke prevention
  • ENDOCRINOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Glyburide
      G6PD
      Diabetes
      Chlorpropamide
      G6PD
      Diabetes
      Glimepiride
      G6PD; CYP2C9
      Diabetes
      Glipizide
      G6PD
      Diabetes
  • GASTROENTEROLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Dexlansoprazole
      (Dexilant ®)
      CYP2C19
      Heartburn, gastroesophageal reflux disease, and esophageal damage
      Esomeprazole
      (Nexium ®)
      CYP2C19
      Acid indigestion, peptic ulcer disease, and gastroesophageal reflux disease
      Lansoprazole (Prevacid ®)
      CYP2C19
      Peptic ulcer disease, gastroesophageal reflux disease
      PEG-3350, sodium sulfate, sodium chloride, potassium chloride, sodium ascorbate, and ascorbic acid
      (Moviprep ®)
      G6PD
      Laxative
      Rabeprazole (Aciphex ®)
      CYP2C19
      Gastroesophageal reflux disease
  • HEMATOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Eltrombopag
      (Promacta ®)
      F5; SERPINC1
      Thrombocytopenia, aplastic anemia
      Methylene blue
      (Provayblue™)
      G6PD
      Methemoglobinemia
  • IMMUNOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Indacaterol
      (Arcapta ®)
      UGT1A1
      COPD
  • INFECTIOUS DISEASE
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Abacavir
      (Ziagen ®)
      HLA-B*57:01
      HIV
      Atazanavir
      (Reyataz ®)
      UGT1A1
      HIV
      Boceprevir
      (Victrelis ®)
      IFNL3
      Hepatitis C
      Chloroquine
      (Aralen ®)
      G6PD
      Malaria
      Dapsone
      G6PD
      Leprosy
      Isoniazid
      (Nydrazid ®)
      NAT1; NAT2
      Tuberculosis
      Mafenide
      (Sulfamylon ®)
      G6PD
      Burns
      Maraviroc
      (Selzentry ®)
      CCR5 receptor
      HIV
      Nitrofurantoin
      (Furadantin ®)
      G6PD
      Urinary tract infections
      Peginterferon alfa-2b
      (Pegasys ®)
      IL28B
      Hepatitis B, hepatitis C
      Primaquine
      G6PD
      Malaria
      Pyrazinamide
      (Rifater ®)
      NAT1; NAT2
      Tuberculosis
      Quinine sulfate
      G6PD; CYP2D6; CYP3A4
      Malaria
      Rifampin
      (Rifadin ®)
      NAT1; NAT2
      Tuberculosis
      Sulfamethox-azole and trimethoprim
      (Bactrim ®)
      G6PD
      Bacterial infections
      Telaprevir
      (Incivek ®)
      IFNL3
      Hepatitis C
      Voriconazole
      (Vfend ®)
      CYP2C19
      Fungal infections
  • METABOLIC
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Allopurinol
      HLA-B*58:01
      High blood uric acid levels, gout
  • NEUROLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Carbamazepine
      (Tegretol ®)
      HLA-B*15:02; HLA-A*31:01
      Epilepsy, bipolar disorder
      Carisoprodol
      (Soma ®)
      CYP2C19
      Musculoskeletal pain
      Clobazam
      (Onfi ®)
      CYP2C19
      Lennox-Gastaut syndrome
      Dextrometorphan & Quinidine
      (Nuedexta ®)
      CYP2D6
      Pseudobulbar affect
      Divalproex
      (Depakote ®)
      UCD (NAGS; CPS; ASS; OTC; ASL; ARG)
      Bipolar disorder (antiepileptic drug)
      Phenytoin
      (Dilantin ®)
      HLA-B; CYP2C9
      Prevention of seizures
      Tetrabenazine
      (Xenazine ®)
      CYP2D6
      Huntington's disease
      Valproic acid
      (Depakene ®)
      OTC; POLG; NAGS; CPS1; ASS1; ASL; ABL2
      Epilepsy
      Vortioxetine
      (Trintellix™)
      CYP2D6
      Depression
  • ONCOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      ado-trastuzumab emtansine
      (Kadcyla ®)
      ERBB2
      Breast cancer
      Afatinib
      (Gilotrif ®)
      EGFR
      Metastatic non-small cell lung cancer
      Anastrozole
      (Arimidex ®)
      ESR1; PGR
      Breast cancer
      Arsenic trioxide
      (Trisenox ®)
      PML-RARA
      Acute promyelocytic leukemia
      Busulfan
      (Busulfex ® & Myleran ®)
      BCR-ABL1
      Leukemia
      Bosutinib
      (Bosulif ®)
      BCR-ABL1
      Leukemia
      Brentuximab Vedotin
      (Adcetris™)
      CD30
      Hodgkin's lymphoma, anaplastic large cell lymphoma
      Capecitabine
      (Xeloda ®)
      DPYD
      Multiple cancers
      Cetuximab
      (Erbitux ®)
      EGFR, KRAS
      Colon cancer
      Crizotinib
      (Xalkori ®)
      ALK
      Lung cancer
      Dabrafenib
      (Tafinlar ®)
      BRAF; G6PD
      Melanoma
      Dasatinib
      (Sprycel ®)
      BCR-ABL
      Leukemia
      Denileukin diftitox
      (Ontak ®)
      IL2RA
      Lymphoma
      Erlotinib
      (Tarceva ®)
      EGFR
      Non-small cell lung cancer
      Everolimus
      (Afinitor ®)
      ERBB2; ESR1
      Breast cancer
      Exemestane
      (Aromasin ®)
      ESR1; PGR
      Breast cancer
      5-Fluorouracil
      (5-FU)
      (Efudex ®)
      DPYD
      Multiple cancers
      Fulvestrant
      (Faslodex ®)
      ESR1; PGR
      Breast cancer
      Gefitinib
      (Iressa ®)
      EGFR
      Non-small cell lung cancer
      Imatinib
      (Gleevec ®)
      BCR-ABL; PDGFRB; KIT; FIP1L1-PDGFRA
      Multiple cancers, myelodysplastic syndrome
      Irinotecan
      (Camptosar ®)
      UGT1A1
      Colon cancer, small cell lung cancer
      Lapatinib
      (Tykerb ®)
      ERBB2; HLA-DQA1; HLA-DRB1
      Breast cancer
      Lenalidomide
      (Revlimid ®)
      Del (5q)
      Multiple myeloma, mantle cell lymphoma, and myelodysplastic syndrome
      Letrozole
      (Femara ®)
      ESR1; PGR
      Breast cancer
      Mercaptopurine
      (Purinethol ®)
      TPMT
      Acute lymphocytic leukemia, chronic myeloid leukemia, Crohn's disease, ulcerative colitis
      Nilotinib
      (Tasigna ®)
      UGT1A1; BCR-ABL1
      Chronic myelogenous leukemia
      Obinutuzumab
      (Gazyva ®)
      MS4A1
      Chronic lymphocytic leukemia, follicular lymphoma
      Omacetaxine mepesuccinate
      (Synribo ®)
      BCR-ABL1
      Chronic myeloid leukemia
      Panitumumab
      (Vectibix ®)
      EGFR; KRAS
      Colon cancer
      Pemetrexed
      (Alimta ®)
      TS
      Lung cancer
      Pertuzumab
      (Perjeta ®)
      ERBB2
      Breast cancer
      Platinum Therapies


      Carboplatin
      ERCC1
      Ovarian cancer
      Cisplatin
      TPMT
      Multiple cancers
      Oxaliplatin
      ERCC1
      Colorectal cancer
      Nedaplatin
      ERCC1
      Multiple cancers
      Triplatin tetranitrate
      ERCC1
      Multiple cancers
      Satraplatin
      ERCC1
      Multiple cancers
      Ponatinib
      (Iclusig ®)
      BCR-ABL1
      Chronic lymphocytic leukemia, acute lymphocytic leukemia
      Rituximab
      (Rituxan ®)
      MS4A1
      Non-Hodgkin's lymphoma, chronic lymphocytic leukemia, and autoimmune diseases
      Tamoxifen
      (Nolvadex ®)
      ESR1; ESR2; PGR; F5; F2; CYP2D6
      Breast cancer
      Thioguanine
      (Tabloid ®)
      TPMT
      Acute myeloid leukemia, acute lymphocytic leukemia, and chronic myeloid leukemia
      Tositumomab
      (Bexxar ®)
      MS4A1
      Non-Hodgkin's lymphoma
      Trametinib
      (Mekinist ®)
      BRAF
      Melanoma
      Trastuzumab
      (Herceptin ®)
      ERBB2
      Breast cancer
      Tretinoin
      (Vesanoid ®)
      PML/RARalpha
      Acute promyelocytic leukemia
      Vemurafenib
      (Zelboraf™)
      BRAF; NRAS
      Melanoma
  • PSYCHIATRY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Aripiprazole
      (Abilify ®)
      CYP2D6
      Schizophrenia, bipolar disorder
      Amitriptyline
      (Elavil ®)
      CYP2C19
      Depression
      Atomoxetine
      (Strattera ®)
      CYP2D6
      ADHD
      Citalopram
      (Celexa ®)
      CYP2C19
      Depression
      Clomipramine
      (Anafranil ®)
      CYP2D6
      Depression
      Clozapine
      (Clozaril ®)
      CYP2D6
      Schizophrenia
      Desipramine
      (Norpramin ®)
      CYP2D6
      Depression
      Doxepin
      (Silenor ®)
      CYP2C19
      Insomnia, depression
      Fluoxetine
      (Prozac ®)
      CYP2D6
      Depression
      Fluvoxamine
      (Luvox CR ®)
      CYP2D6
      Obsessive compulsive disorders
      Iloperidone
      (Fanapt ®)
      CYP2D6
      Schizophrenia
      Imipramine
      (Tofranil-PM ®)
      CYP2C19
      Depression
      Nortriptyline
      (Pamelor ®)
      CYP2D6
      Depression
      Paroxetine
      (Pexeva ®)
      CYP2D6
      Major depressive disorder, obsessive compulsive disorder, panic disorder, and generalized anxiety disorder
      Perphenazine
      (Trilafon ®)
      CYP2D6
      Schizophrenia
      Pimozide
      (Orap ®)
      CYP2D6
      Tourette's syndrome
      Protriptyline
      (Vivactil ®)
      CYP2D6
      Depression
      Risperidone
      CYP2D6
      Schizophrenia, bipolar mania, irritability with autistic disorder
      Thioridazine
      (Mellaril ®)
      CYP2D6
      Schizophrenia
      Trimipramine
      (Surmontil ®)
      CYP2C19
      Depression
  • PULMONARY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Ivacaftor
      (Kalydeco ®)
      CFTR
      Cystic fibrosis
  • RHEUMATOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Azathioprine
      (Imuran ®)
      TPMT
      Rheumatoid arthritis, organ transplant
      Flurbiprofen
      (Ansaid ®)
      CYP2C9
      Arthritis
      Pegloticase
      (Krystexxa ®)
      G6PD
      Uric acid management, gout
  • TOXICOLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Sodium nitrate
      G6PD
      Cyanide poisoning
  • TRANSPLANTATION
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Mycophenolic acid
      (Myfortic ®)
      HPRT1
      Kidney transplant
      Tacrolimus
      CYP3A5
      Organ transplant
  • UROLOGY
    • Drug Name
      (Brand Name)

      Biomarker(s)
      Indication
      Tolterodine
      (Detrol ®)
      CYP2D6
      Overactive bladder

If you have suggestions or updates for this page please contact Daryl Pritchard at dpritchard@personalizedmedicinecoalition.org.